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Journal of Bacteriology, September 2009, p. 5865-5867, Vol. 191, No. 18
0021-9193/09/$08.00+0     doi:10.1128/JB.00683-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Region of Difference 1 in Nontuberculous Mycobacterium Species Adds a Phylogenetic and Taxonomical Character{triangledown}

Jakko van Ingen,1,2* Rina de Zwaan,1 Richard Dekhuijzen,2 Martin Boeree,2 and Dick van Soolingen1

National Mycobacteria Reference Laboratory, Laboratories for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands,1 Department of Pulmonary Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands2

Received 26 May 2009/ Accepted 14 July 2009

The esat-6 and cfp-10 genes are essential for virulence in Mycobacterium tuberculosis. Among nontuberculous mycobacteria, we found these genes only in M. kansasii, M. szulgai, M. marinum, and M. riyadhense, with unique sequences. This adds a phylogenetic and taxonomical characteristic and may represent a virulence factor for nontuberculous mycobacteria.

* Corresponding author. Mailing address: RIVM, LIS, National Mycobacteria Reference Laboratory, Antonie van Leeuwenhoeklaan 9, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Phone: 31-30-2742886. Fax: 31-30-2744418. E-mail: jakko.van.ingen{at}rivm.nl

{triangledown} Published ahead of print on 17 July 2009.

Journal of Bacteriology, September 2009, p. 5865-5867, Vol. 191, No. 18
0021-9193/09/$08.00+0     doi:10.1128/JB.00683-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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