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Journal of Bacteriology, September 2009, p. 5868-5872, Vol. 191, No. 18
0021-9193/09/$08.00+0     doi:10.1128/JB.00623-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Staphylococcus aureus YoeB Homologues Inhibit Translation Initiation{triangledown}

Satoshi Yoshizumi,1 Yonglong Zhang,1 Yoshihiro Yamaguchi,1 Liang Chen,2 Barry N. Kreiswirth,2 and Masayori Inouye1*

Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854,1 Public Health Research Institute Tuberculosis Center, International Center for Public Health, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 071032

Received 12 May 2009/ Accepted 30 June 2009

YoeB is a bacterial toxin encoded by the yefM-yoeB toxin-antitoxin system found in various bacterial genomes. Here, we show that Staphylococcus aureus contains two YoeB homologues, both of which function as ribosome-dependent mRNA interferases to inhibit translation initiation in a manner identical to that of YoeB-ec from Escherichia coli.

* Corresponding author. Mailing address: Department of Biochemistry, 675 Hoes Lane, Piscataway, NJ 08854. Phone: (732) 235-4116. Fax: (732) 235-4559. E-mail: Inouye{at}umdnj.edu

{triangledown} Published ahead of print on 6 July 2009.

Journal of Bacteriology, September 2009, p. 5868-5872, Vol. 191, No. 18
0021-9193/09/$08.00+0     doi:10.1128/JB.00623-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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