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Journal of Bacteriology, January 2009, p. 673-677, Vol. 191, No. 2
0021-9193/09/$08.00+0     doi:10.1128/JB.01256-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Streptococcus pyogenes CovRS Mediates Growth in Iron Starvation and in the Presence of the Human Cationic Antimicrobial Peptide LL-37 {triangledown}

Barbara J. Froehlich, Christopher Bates, and June R. Scott*

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322

Received 8 September 2008/ Accepted 30 October 2008

We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322. Phone: (404) 727-0402. Fax: (404) 727-8999. E-mail: scott{at}microbio.emory.edu

{triangledown} Published ahead of print on 7 November 2008.

Journal of Bacteriology, January 2009, p. 673-677, Vol. 191, No. 2
0021-9193/09/$08.00+0     doi:10.1128/JB.01256-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Santi, I., Grifantini, R., Jiang, S.-M., Brettoni, C., Grandi, G., Wessels, M. R., Soriani, M. (2009). CsrRS Regulates Group B Streptococcus Virulence Gene Expression in Response to Environmental pH: a New Perspective on Vaccine Development. J. Bacteriol. 191: 5387-5397 [Abstract] [Full Text]  


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