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Journal of Bacteriology, November 2009, p. 6769-6772, Vol. 191, No. 21
0021-9193/09/$08.00+0     doi:10.1128/JB.00431-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Identification of a Polyprenylphosphomannosyl Synthase Involved in the Synthesis of Mycobacterial Mannosides{triangledown} ,{dagger}

Hataichanok Scherman, Devinder Kaur, Ha Pham, Henrieta Skovierová, Mary Jackson, and Patrick J. Brennan*

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523

Received 30 March 2009/ Accepted 16 August 2009

We report on the identification of a glycosyltransferase (GT) from Mycobacterium tuberculosis H37Rv, Rv3779, of the membranous GT-C superfamily responsible for the direct synthesis of polyprenyl-phospho-mannopyranose and thus indirectly for lipoarabinomannan, lipomannan, and the higher-order phosphatidyl-myo-inositol mannosides.

* Corresponding author. Mailing address: Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523-1682. Phone: (970) 491-6700. Fax: (970) 491-1815. E-mail: Patrick.Brennan{at}colostate.edu

{triangledown} Published ahead of print on 28 August 2009.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, November 2009, p. 6769-6772, Vol. 191, No. 21
0021-9193/09/$08.00+0     doi:10.1128/JB.00431-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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