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Journal of Bacteriology, November 2009, p. 7134-7139, Vol. 191, No. 22
0021-9193/09/$08.00+0     doi:10.1128/JB.01000-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

YjhS (NanS) Is Required for Escherichia coli To Grow on 9-O-Acetylated N-Acetylneuraminic Acid{triangledown}

Susan M. Steenbergen, Jamie L. Jirik, and Eric R. Vimr*

Laboratory of Sialobiology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802

Received 28 July 2009/ Accepted 3 September 2009

The nanATEK-yhcH, yjhATS, and yjhBC operons in Escherichia coli are coregulated by environmental N-acetylneuraminic acid, the most prevalent sialic acid in nature. Here we show that YjhS (NanS) is a probable 9-O-acetyl N-acetylneuraminic acid esterase required for E. coli to grow on this alternative sialic acid, which is commonly found in mammalian host mucosal sites.


* Corresponding author. Mailing address: 2522 VMBSB, 2001 South Lincoln Avenue, Urbana, IL 61802. Phone: (217) 333-8502. Fax: (217) 244-7421. E-mail: ervimr{at}illinois.edu

{triangledown} Published ahead of print on 11 September 2009.


Journal of Bacteriology, November 2009, p. 7134-7139, Vol. 191, No. 22
0021-9193/09/$08.00+0     doi:10.1128/JB.01000-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.