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Journal of Bacteriology, March 2009, p. 1979-1981, Vol. 191, No. 6
0021-9193/09/$08.00+0     doi:10.1128/JB.01549-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Rcs Two-Component System Regulates Expression of Lysozyme Inhibitors and Is Induced by Exposure to Lysozyme{triangledown}

Lien Callewaert, Kristof G. A. Vanoirbeek, Ine Lurquin, Chris W. Michiels, and Abram Aertsen*

Laboratory of Food Microbiology and Leuven Food Science and Nutrition Research Center (LFoRCe), Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, B-3001 Leuven, Belgium

Received 31 October 2008/ Accepted 5 January 2009

The Escherichia coli Rcs regulon is triggered by antibiotic-mediated peptidoglycan stress and encodes two lysozyme inhibitors, Ivy and MliC. We report activation of this pathway by lysozyme and increased lysozyme sensitivity when Rcs induction is genetically blocked. This lysozyme sensitivity could be alleviated by complementation with Ivy and MliC.

* Corresponding author. Mailing address: Laboratory of Food Microbiology, Kasteelpark Arenberg 22, B-3001 Leuven, Belgium. Phone: 32-16-321752. Fax: 32-16-321960. E-mail: abram.aertsen{at}biw.kuleuven.be

{triangledown} Published ahead of print on 9 January 2009.

Journal of Bacteriology, March 2009, p. 1979-1981, Vol. 191, No. 6
0021-9193/09/$08.00+0     doi:10.1128/JB.01549-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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