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Journal of Bacteriology, April 2009, p. 2888-2893, Vol. 191, No. 8
0021-9193/09/$08.00+0     doi:10.1128/JB.01773-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Differential Expression of sigH Paralogs during Growth and under Different Stress Conditions in Mycobacterium smegmatis{triangledown} ,{dagger}

Anirudh K. Singh and Bhupendra N. Singh*

Division of Microbiology, Central Drug Research Institute, Lucknow 226 001, India

Received 18 December 2008/ Accepted 6 February 2009

SigH regulates a transcriptional network that responds to heat and oxidative stress in mycobacteria. Seven sigH paralogs are reported to exist in the Mycobacterium smegmatis genome. A comprehensive real-time reverse transcriptase PCR analysis during different stages of growth and upon exposure to various stress conditions and antimycobacterial compounds showed differential expression of sigH paralogs during stationary phase and severalfold increases in the levels of transcription of sigH1, sigH4, sigH5, sigH6, and sigH7 under specific stress conditions.

* Corresponding author. Mailing address: Division of Microbiology, Central Drug Research Institute, Lucknow 226 001, India. Phone: 91-522-2612411. Fax: 91-522-2623405. E-mail: bhupendransingh{at}gmail.com

{triangledown} Published ahead of print on 13 February 2009.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, April 2009, p. 2888-2893, Vol. 191, No. 8
0021-9193/09/$08.00+0     doi:10.1128/JB.01773-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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