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J Bacteriol. 1961 July; 82(1): 20-25
Copyright ©, 1961, The Williams & Wilkins Company. All Rights Reserved.

AMINO ACID INTERACTIONS IN NEUROSPORA CRASSA

Department of Physiological Chemistry, University of California, Los Angeles 24, California

ABSTRACT

SOBOREN, JOSEPHINE (University of California, Los Angeles), AND JOSEPH F. NYC. Amino acid interactions in Neurospora crassa. J. Bacteriol. 82:20–25. 1961.—A systematic study of the effects of the naturally occurring amino acids on the growth of a wild-type strain of Neurospora crassa focused attention upon L-tryptophan, which exhibits a strong growth inhibitory effect. Further investigation disclosed that other tryptophan metabolites, anthranilic acid, indole, kynurenine, and 3-hydroxykynurenine also inhibit growth. The proposed antimetabolic role of these aromatic compounds explains the poor growth response of certain tryptophan-requiring strains of N. crassa to tryptophan supplements. The growth of normal and mutant strains of N. crassa on media supplemented with tryptophan is influenced by the presence of other amino acids.