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J Bacteriol. 1961 July; 82(1): 94-100
Copyright ©, 1961, The Williams & Wilkins Company. All Rights Reserved.

ENZYME SYSTEMS IN THE MYCOBACTERIA XI.

Evidence for a Functional Glycolytic System

^a Tuberculosis Research Laboratory, Veterans Administration Hospital, the Department of Bacteriology and the Institute for Enzyme Research, University of Wisconsin, Madison, Wisconsin

ABSTRACT

BASTARRACHEA, FERNANDO (University of Wisconsin, Madison), DAVID G. ANDERSON, AND DEXTER S. GOLDMAN. Enzyme systems in the mycobacteria. XI. Evidence for a functional glycolytic system. J. Bacteriol. 82:94–100. 1961.—Cell-free extracts of the H37Ra strain of Mycobacterium tuberculosis contain the enzymes, aldolase, phosphohexokinase, phosphohexoisomerase, and phosphoglucomutase. The first three enzymes have been purified; the characteristics of all these enzymes have been studied. The enzymes are similar to those isolated from animal tissue. A functional glycolytic system in the mycobacteria provides a mechanism for the formation of other metabolites from glycerol.

¹ Present address: Unidad de Patología, Escuela de Medicina, Hospital General, México 7, D.F., México. Some of this work is taken from the thesis of Fernando Bastarrachea, submitted to the Graduate Division, University of Wisconsin, in partial fulfillment of the requirements for the M.S. degree (Bacteriology), 1959. On leave from the University of Mexico Medical School.

² Present address: Radioisotope Service, Veterans Administration Hospital, Madison, Wis.