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J Bacteriol. 1961 September; 82(3): 411-417
Copyright ©, 1961, The Williams & Wilkins Company. All Rights Reserved.

ACTION OF PENICILLIN ON AEROBACTER CLOACAE

Department of Pharmacy, University of Nottingham, Nottingham, England

ABSTRACT

HUGO, W. B. (University of Nottingham, Nottingham, England), AND A. D. RUSSELL. Action of penicillin on Aerobacter cloacae. J. Bacteriol. 82:411–417. 1961.—A study has been made of the action of penicillin on a penicillinase-producing strain of Aerobacter cloacae. It has been found that in culture media rendered hypertonic by the addition of sucrose (0.33 to 0.66 M), provided a source of magnesium ions is present, cell wall lesions occur, giving rise to osmotically fragile spheroplasts. Evidence is also presented of a lethal effect not associated with cell wall damage. Penicillinase production is not a complete challenge to the action of penicillin and in certain experimental situations renders the cells more susceptible to penicillin action.