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J Bacteriol. 1961 December; 82(6): 793-797
Copyright © 1961, The Williams & Wilkins Company. All Rights Reserved.

SURVEY OF FOURTEEN METABOLIC INHIBITORS FOR THEIR EFFECT ON ENDOSPORE GERMINATION IN BACILLUS SUBTILIS¹

^a Dairy Products Laboratory, Eastern Utilization Research and Development Division, Agricultural Research Service, U. S. Department of Agriculture, Washington, D. C.
^b Laboratory of Bacteriology, State College of Agriculture, Cornell University, Ithaca, New York

ABSTRACT

CURRAN, HAROLD R. (U. S. Department of Agriculture, Washington, D. C.) AND GEORGES KNAYSI. Survey of fourteen metabolic inhibitors for their effect on endospore germination in Bacillus subtilis. J. Bacteriol. 82:793–797. 1961.—Phase contrast microscopy was used to study the effects of metabolic antagonists upon incipient spore germination in glucose agar-film microcultures. The period of observation was 1 to 2 hr. Of 14 compounds tested, only ethanol in 10% concentration (v/v) caused almost complete inhibition. Oxamic acid and DL-ethionine were slightly stimulatory; 6-methyl thiouracil and octyl aldehyde were without effect. The inhibiting effect of the remainder depended upon the concentration of the antagonist. The stimulating effect of glucose on germination is discussed.

¹ This study was carried out in the Dairy Products Laboratory, Eastern Utilization Research and Development Division, Agricultural Research Service, U. S. Department of Agriculture, Washington, D. C.