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J Bacteriol. 1962 February; 83(2): 297-300
Copyright © 1962, The Williams & Wilkins Company. All Rights Reserved.

PROPERTIES OF TWO REGULATING GENES FOR ALKALINE PHOSPHATASE

Biology Division, University of Pennsylvania, Philadelphia, Pennsylvania
Biochemistry Department, University of Wisconsin, Madison, Wisconsin

ABSTRACT

GAREN, A. (University of Pennsylvania, Philadelphia) AND H. ECHOLS. Properties of two regulating genes for alkaline phosphatase. J. Bacteriol. 83:297–300. 1962.—A constitutive mutation in one of the two regulating genes for alkaline phosphatase has two effects on the synthesis of the enzyme: repression of synthesis is blocked, and the cell's capacity to produce the enzyme is reduced. The behavior of this type of mutation has been studied in heterozygotes. The results suggest that the product of this regulating gene functions as an inducer as well as a repressor.