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J Bacteriol. 1962 July; 84(1): 154-156
Copyright © 1962, The Williams & Wilkins Company. All Rights Reserved.

REVERSAL OF D-CYCLOSERINE INHIBITION OF BACTERIAL GROWTH BY ALANINE

Department of Nutritional and Biochemical Research, Mead Johnson Research Center, Mead Johnson & Co., Evansville, Indiana

ABSTRACT

ZYGMUNT, WALTER A. (Mead Johnson & Co., Evansville, Ind.). Reversal of D-cycloserine inhibition of bacterial growth by alanine. J. Bacteriol. 84:154–156. 1962.—Reversal of the antibacterial activity of D-4-amino-3-isoxazolidone by alanine in bacterial cultures actively growing on chemically defined media was compared in cultures requiring exogenous alanine and those capable of its synthesis. DL-Alanine was the most effective reversal agent in Pediococcus cerevisiae, an alanine-requiring organism, and D-alanine was effective in Escherichia coli and Staphylococcus aureus, organisms synthesizing alanine. With all three cultures, L-alanine was the least effective reversal agent.