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J Bacteriol. 1962 September; 84(3): 389-392
Copyright © 1962, The Williams & Wilkins Company. All Rights Reserved.

THERMAL INACTIVATION OF POLIOVIRUS UNDER ANAEROBIC CONDITIONS

Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas

ABSTRACT

WALLIS, CRAIG (Baylor University, Houston, Texas) AND JOSEPH L. MELNICK. Thermal inactivation of poliovirus under anaerobic conditions. J. Bacteriol. 84:389–392. 1962.—Of the six strains of poliovirus tested (three antigenic types), none was stabilized at 50 C under anaerobic conditions. The previously reported stabilization of polioviruses using thioglycolate had been attributed to anaerobic conditions. However, the sparing effect attained with high concentrations of thioglycolate was achieved as readily with other organic salts (benzoate, acetate) which could not be attributed to the anaerobic state. The viruses failed to be stabilized when low oxygen tension was obtained by dilute thioglycolate, L-cysteine, and nitrogen.