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J Bacteriol. 1962 September; 84(3): 466-472
Copyright © 1962, The Williams & Wilkins Company. All Rights Reserved.

EFFECT OF A RETICULOENDOTHELIAL STIMULATING AGENT (RESTIM) ON RESISTANCE OF MICE

New England Institute for Medical Research, Ridgefield, Connecticut

ABSTRACT

RANSOM, JOHN P. (New England Institute for Medical Research, Ridgefield, Conn.), VARSENIG Z. PASTERNAK, AND JOHN H. HELLER. Effect of a reticuloendothelial stimulating agent (restim) on resistance of mice. J. Bacteriol. 84:466–472. 1962.—The effect of restim, a preparation of yeast cell walls, on resistance of mice to challenge by Salmonella typhimurium has been investigated. Although restim markedly increases the rate of phagocytosis and clearance of carbon particles, and presumably of viable bacterial cells, this activity has no significant effect on the course of events when restim-treated mice are challenged with S. typhimurium. However, when specific antibody derived from either active or passive immunization of the mice is present, restim significantly enhances resistance as judged by survival time and by 20-day survival.