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J Bacteriol. 1962 November; 84(5): 967-972
Copyright © 1962, The Williams & Wilkins Company. All Rights Reserved.

S-ADENOSYLMETHIONINE IN THE BIOSYNTHESIS OF BACTERIAL FATTY ACIDS

Department of Microbiology and Immunology, Cornell University Medical College, New York, New York

ABSTRACT

O'LEARY, WILLIAM M. (Cornell University Medical College, New York, N.Y.). S-adenosylmethionine in the biosynthesis of bacterial fatty acids. J. Bacteriol. 84:967–972. 1962.—The fatty-acid contents of a wild strain of Aerobacter aerogenes and of three auxotrophic mutants were determined by the use of gas-liquid chromatography. All strains studied exhibited essentially identical fatty-acid spectra. This organism was shown to contain large amounts of a C₁₇ cyclopropane fatty acid, and it is suggested that it may be a convenient natural source of this compound. By use of the auxotrophic mutants which have varying requirements for exogenous sources of methionine and S-adenosylmethionine, it was shown by means of radioisotope tracer techniques that S-adenosylmethionine functions in this organism as a donor of a one-carbon unit that is used to form the ring structure in the biosynthesis of cyclopropane fatty acids.

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