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AMINO ACID CROSS RESISTANCE IN AGROBACTERIUM TUMEFACIENS

Biology Department, Manhattan College, New York, New York

ABSTRACT

BEARDSLEY, ROBERT E. (Manhattan College, New York, N. Y.). Amino acid cross resistance in Agrobacterium tumefaciens. J. Bacteriol. 84:1237–1240. 1962.—Resistant clones selected on medium supplemented with glycine were also resistant to D-methionine, D-valine, DL-norleucine, and DL-serine. Cross resistance was similarly exhibited by clones selected on D-methionine, D-valine, or DL-norleucine. Two types of resistant organisms were observed. One produced colonies containing normal rods on selection medium. The other produced translucent colonies containing L forms. Both grew as typical rods in unsupplemented medium. Some resistant clones did not produce a temperate phage carried by the parental strain, but these retained immunity to homologous phage. The toxicity of D-methionine and D-valine for nonresistant bacteria is not reversed by the L isomers. The lethal effects of toxic amino acids are additive.