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IN VITRO AND IN VIVO LABORATORY EVALUATION OF CEPHALOTHIN, A NEW BROAD SPECTRUM ANTIBIOTIC

The Lilly Research Laboratories, Indianapolis, Indiana

ABSTRACT

BONIECE, W. S. (Lilly Research Laboratories, Indianapolis, Indiana), W. E. WICK, D. H. HOLMES, AND C. E. REDMAN. In vitro and in vivo laboratory evaluation of cephalothin, a new broad-spectrum antibiotic. J. Bacteriol. 84:1292–1296. 1962.—Cephalothin, a new cephalosporin antibiotic, is the sodium salt of 7-(thiophene-2-acetamido) cephalosporanic acid. The activity of this antibiotic against a variety of gram-positive and gram-negative bacteria is described, as determined by the tube-dilution and disc-plate methods. Correlations of the results of the therapy of experimental infections in mice with in vitro sensitivity to cephalothin are presented. The data from the gram-negative bacterial infection tests suggest the following relationship on a within strain basis: ED₅₀ = C_iLD₅₀^b_i, where the subscript i stands for the various strains.