This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zimmerman, L. Search for Related Content PubMed PubMed Citation Articles by Zimmerman, L.

SURVIVAL OF SERRATIA MARCESCENS AFTER FREEZE-DRYING OR AEROSOLIZATION AT UNFAVORABLE HUMIDITY I.

Effects of Sugars

U.S. Army Biological Laboratories, Fort Detrick, Frederick, Maryland

ABSTRACT

ZIMMERMAN, LEONARD (U.S. Army Biological Laboratories, Fort Detrick, Frederick, Md.). Survival of Serratia marcescens after freeze-drying or aerosolization at unfavorable humidity. I. Effects of sugars. J. Bacteriol. 84:1297–1302. 1962.—Suspensions of Serratia marcescens were subjected to freeze-drying or to aerosolization at unfavorable humidity levels. The survival of the cells during one or the other of these treatments was markedly improved in the presence of common sugars, but no one sugar stabilized the cells against both stresses. The protective effects of the sugars were correlated with their penetrability into cells; minimally penetrable sugars stabilized cells against aerosolization, and freely penetrable sugars stabilized cells during freeze-drying. These results were attributed to the modifications of intracellular water content induced by the presence of the sugars in the cell suspensions.