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PRODUCTION OF TOLERANCE TO THE TOXICITY OF CANDIDA ALBICANS BY NONFUNGAL MATERIALS¹

^a Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, U.S. Public Health Service, Bethesda, Maryland

ABSTRACT

HASENCLEVER, H. F. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.) AND W. O. MITCHELL. Production of tolerance to the toxicity of Candida albicans by nonfungal materials. J. Bacteriol. 84:1325–1329. 1962.—Tolerance in mice to the toxic manifestations of viable Candida albicans cells was elicited by injections of Salmonella enteritidis or S. typhosa lipopolysaccharides, or complete Freund's adjuvant. The greatest host stimulation occurred when the lipopolysaccharides were given 1 or 6 days before intravenous challenge. The highest level of tolerance produced by intraperitoneal preinfection with C. albicans was found when the yeast cells were injected 6 days before challenge. Older mice appeared to require larger amounts of endotoxin to demonstrate toxicity tolerance. Protection in mice that received both lipopolysaccharide injections and C. albicans intraperitoneal preinfection was slightly higher than in those mice given only the individual components.

¹ Presented in part at the 1962 Annual Meeting of the American Society for Microbiology, Kansas City, Mo.