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EFFECT OF METHIONINE, NORLEUCINE, AND LYSINE DERIVATIVES ON CEPHALOSPORIN C FORMATION IN CHEMICALLY DEFINED MEDIA

Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey

ABSTRACT

DEMAIN, A. L. (Merck Sharp & Dohme Research Laboratories, Rahway, N.J.), JOANNE F. NEWKIRK, AND D. HENDLIN. Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media. J. Bacteriol. 85: 339–344. 1963.—Chemically defined media were developed for production of cephalosporin C by Cephalosporium sp. In such media, the requirement for methionine can be satisfied by norleucine. Further stimulation of antibiotic production was obtained with the lysine derivatives -N-acetyl-L-lysine and -aminocaproic acid but not with lysine itself. Also inactive were -aminoadipic and ketoadipic acids. Other lysine derivatives were found to inhibit cephalosporin C production at 0.01 M. The final medium supported the production of approximately 0.5 g of cephalosporin C per liter of medium.