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RESPIRATORY INHIBITOR FROM SERRATIA MARCESCENS¹

^a United States Army Biological Laboratories, Fort Detrick, Frederick, Maryland

ABSTRACT

NEUFELD, HAROLD A. (U.S. Army Biological Laboratories, Fort Detrick, Frederick, Md.), RONALD L. COLEMAN, AND JOSEPH S. ZANNUCCI. Respiratory inhibitor from Serratia marcescens. J. Bacteriol. 85:614–618. 1963.—A substance was obtained from Serratia marcescens in conjunction with lipopolysaccharide that is a potent inhibitor of mammalian succinoxidase activity. It was determined that the purified lipopolysaccharide is not an in vitro inhibitor of the succinoxidase system. The inhibitor has no effect on succinic dehydrogenase or cytochrome oxidase but apparently exerts its effect on some portion of the electron-transport chain between the dehydrogenase and cytochrome c.

² Present address: Department of Biochemistry, University of Oklahoma Medical School, Oklahoma City.

¹ A preliminary report on these data was delivered at the Annual Meeting of the American Society of Biological Chemists, Atlantic City, N.J., April 1961.