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J Bacteriol. 1963 March; 85(3): 707-711
Copyright © 1963, The Williams & Wilkins Company. All Rights Reserved.

INHIBITION OF THE GROWTH OF AGENTS OF THE PSITTACOSIS GROUP BY D-CYCLOSERINE AND ITS SPECIFIC REVERSAL BY D-ALANINE1

James W. Moulder, Dorothy L. Novosel and Julius E. Officer2

a Department of Microbiology, University of Chicago, Chicago, Illinois

ABSTRACT

MOULDER, JAMES W. (University of Chicago, Chicago, Ill.), DOROTHY L. NOVOSEL, AND JULIUS E. OFFICER. Inhibition of the growth of agents of the psittacosis group by D-cycloserine and its specific reversal by D-alanine. J. Bacteriol. 85:707–711. 1963.—D-Cycloserine inhibited multiplication of four members of the psittacosis group in chick embryo yolk sac. D-Alanine reversed each inhibition. In infections with the agent of mouse pneumonitis, the most sensitive member of the psittacosis group tested, D-alanine competitively antagonized the growth inhibition produced by D-cycloserine. Of a number of other potential reversing agents, only DL-alanyl-DL-alanine reversed the effect of D-cycloserine on mouse pneumonitis agent. The significance of the susceptibility of the psittacosis group to D-cycloserine is discussed in light of the known mode of action of this antibiotic on bacteria.

FOOTNOTES

2 Present address: Virus and Rickettsia Division, U.S. Army Chemical Corps Biological Laboratories, Fort Detrick, Frederick, Md.

1 A preliminary account of this work was presented at the Annual Meeting of the American Society for Microbiology, Kansas City, Mo., May 6 to 10, 1962.

J Bacteriol. 1963 March; 85(3): 707-711
Copyright © 1963, The Williams & Wilkins Company. All Rights Reserved.



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