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EFFECTS OF THE ANTIFUNGAL PEPTIDE Ro 2-7758 ON MORPHOLOGY OF MUCOR CORYMBIFERA

The Veterans Administration Hospital, and the Departments of Physiology and Pharmacology and of Pathology, Duke University Medical Center, Durham, North Carolina

ABSTRACT

GALE, GLEN R. (Veterans Administration Hospital and Duke University Medical Center, Durham, N.C.). Effects of the antifungal peptide Ro 2-7758 on morphology of Mucor corymbifera. J. Bacteriol. 85:833–837. 1963.—Hyphae of Mucor corymbifera grown in the presence of the antifungal peptide, Ro 2-7758, were examined in an electron microscope. The predominant change, compared with control hyphae, was a marked thickening of the cell wall, with apparent maintenance of normal structure. Cell walls of control hyphae were from 0.03 to 0.11 µ in thickness; drug-treated walls varied from 0.22 to over 0.75 µ in thickness. The possible sites and mechanisms of action, as well as the significance of a thickened cell wall in antibiosis, are discussed.