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EFFECTS OF CERTAIN AMINO ACIDS ON ANTHRANILATE PRODUCTION IN NEUROSPORA CRASSA

Department of Physiological Chemistry, University of California at Los Angeles, Los Angeles, California

ABSTRACT

SOBOREN, JOSEPHINE (University of California, Los Angeles) AND JOSEPH F. NYC. Effects of certain amino acids on anthranilate production in Neurospora crassa. J. Bacteriol. 85:881–888. 1963.—The level of anthranilic acid produced in cultures of a tryptophanless mutant of Neurospora crassa strain C-83 was closely related to the growth response. A good growth response was attained only on supplements which greatly repressed the level of anthranilate accumulated. The improved growth response of strain C-83 to variable levels of tryptophan and to supplements of the amino acids phenylalanine, tyrosine, leucine, and methionine was correlated with a decreased anthranilate production. The inhibitory effect of these supplements on anthranilate production was ascribed to effects on the mechanisms which regulate the formation of anthranilic acid.