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ANTAGONISM OF D-CYCLOSERINE INHIBITION OF MYCOBACTERIAL GROWTH BY D-ALANINE

Department of Microbiology and Natural Products Research, Research Center, Mead Johnson & Company, Evansville, Indiana

ABSTRACT

ZYGMUNT, WALTER A. (Mead Johnson & Co., Evansville, Ind.). Antagonism of D-cycloserine inhibition of mycobacterial growth by D-alanine. J. Bacteriol. 85:1217–1220. 1963.—Reversal of the antimycobacterial activity of D-4-amino-3-isoxazolidinone (D-cycloserine) by alanine in two species of mycobacteria actively growing on chemically defined media was compared. In both instances, D-alanine was the most effective reversal agent. The specificity with which the D isomer reversed the antimycobacterial activity of D-cycloserine was more pronounced than that observed with other species of bacteria. Mycobactin, a growth factor for certain mycobacteria, showed no reversal activity.

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