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NEISSERIA GONORRHOEAE I.

Virulence Genetically Linked to Clonal Variation

Venereal Disease Research Laboratory, Venereal Disease Branch, Communicable Disease Center, U.S. Public Health Service, Atlanta, Georgia

ABSTRACT

KELLOGG, DOUGLAS S., JR. (Communicable Disease Center, Atlanta, Ga.), WILLIAM L. PEACOCK, JR., W. E. DEACON, L. BROWN, AND CARL I. PIRKLE. Neisseria gonorrhoeae. I. Virulence genetically linked to clonal variation. J. Bacteriol. 85:1274–1279. 1963.—One type, obtained from the purulent exudate of acute gonorrhea was maintained by 69 selective in vitro passages, at which point the organisms produced infections in human volunteers. A predominance of clonal types found in laboratory strains and a lack of ability to infect human volunteers resulted from 69 nonselective in vitro passages. Physiological and serological characteristics of the clonal types are compared. We are now in a position to study Neisseria gonorrhoeae organisms in their virulent form.

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