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ACTION OF FORMALDEHYDE ON MICROORGANISMS II.

Formation of 1,3-Thiazane-4-Carboxylic Acid in Aerobacter Aerogenes Treated with Formaldehyde

Biochemical Research Laboratory, The Dow Chemical Company, Midland, Michigan

ABSTRACT

NEELY, W. BROCK (The Dow Chemical Co., Midland, Mich.). Action of formaldehyde on microorganisms. II. Formation of 1,3-thiazane-4-carboxylic acid in Aerobacter aerogenes treated with formaldehyde. J. Bacteriol. 85:1420–1422. 1963.—A culture of Aerobacter aerogenes was found to incorporate C¹⁴-labeled formaldehyde into 1,3-thiazane-4-carboxylic acid. The reaction was found to proceed nonenzymatically from homocysteine and formaldehyde. As a consequence of this reaction, the ability of homocysteine to counteract the effects of formaldehyde on A. aerogenes was investigated.