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GROWTH INHIBITORY PROPERTIES OF MYCOPLASMA ANTIBODY

Arthritis Research Unit, Department of Medicine, The George Washington University, Washington, D.C

ABSTRACT

BAILEY, JACK S. (The George Washington University, Washington, D.C.), HAROLD W. CLARK, WILLIAM R. FELTS, AND THOMAS MCP. BROWN. Growth inhibitory properties of Mycoplasma antibody. J. Bacteriol. 86:147–150. 1963.—A substance in antiserum responsible for growth inhibition of Mycoplasma was found to be associated with the water-insoluble globulin fraction. This fraction and the agglutinins removed from agglutinated antigen inhibited the growth of Mycoplasma in a similar manner. Sonic oscillation of antiserum broth cultures partially relieved the growth inhibition. The results of this study suggest the existence of neutralized Mycoplasma in a latent phase, which could explain their infrequent detection in tissues and fluids. The application of such techniques as sonic oscillation may improve the recovery and identification of Mycoplasma from these sources.