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STUDIES ON THE PHYSIOLOGY OF RICKETTSIAE V.

Metabolism of Carbamyl Phosphate by Coxiella burnetii

Department of Bacteriology, University of Kansas, Lawrence, Kansas

ABSTRACT

MALLAVIA, L. (University of Kansas, Lawrence) AND D. PARETSKY. Studies on the physiology of rickettsiae. V. Metabolism of carbamyl phosphate by Coxiella burnetii. J. Bacteriol. 86:232–238. 1963.—Preparations of disrupted Coxiella burnetii catalyze synthesis of citrulline from ornithine and carbamyl phosphate at an optimal pH of 7.0 to 7.5. Rickettsial synthesis of the pyrimidine precursor, ureidosuccinate, is demonstrated and confirmed by isolating C¹⁴-labeled ureidosuccinate from reaction mixtures of carbamyl phosphate and labeled aspartate. The data suggest a further rickettsial synthesis of orotate and imply rickettsial competence for host-independent pyrimidine synthesis.

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