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EPIMERIZATION OF THYMIDINE DIPHOSPHATE GLUCOSE IN BACTERIAL EXTRACTS

^a Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri

ABSTRACT

TINELLI, REGINA (Washington University School of Medicine, St. Louis, Mo.), A. M. MICHELSON, AND JACK L. STROMINGER. Epimerization of thymidine diphosphate glucose in bacterial extracts. J. Bacteriol. 86:246–251. 1963.—Extracts of Pasteurella pseudotuberculosis type IV and several other bacteria catalyzed the reversible interconversion of thymidine diphosphate (TDP)-D-glucose and TDP-D-galactose. Moreover, extracts of P. pseudotuberculosis catalyzed the synthesis of TDP-D-glucose from thymidine triphosphate and -D-glucose-1-phosphate. The limitations of these observations and their possible significance are discussed.

¹ Present address: Institut Pasteur, Paris, France.

² Present address: Institut de Biologie Physico-Chimique, Paris, France.