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PHAGOCYTOSIS INHIBITION AND REVERSAL I.

Effect of Glycolytic Intermediates and Nucleotides on Particle Uptake

^a Department of Pathology and Medical Research, St. Margaret's Hospital, Boston, Massachusetts
^b Department of Obstetrics and Gynecology, Tufts University Medical School, Boston, Massachusetts

ABSTRACT

SBARRA, ANTHONY J. (St. Margaret's Hospital, Boston, Mass.) AND WILLIAM SHIRLEY. Phagocytosis inhibition and reversal. I. Effect of glycolytic intermediates and nucleotides on particle uptake. J. Bacteriol. 86:259–265. 1963.—By microscopically monitoring phagocytosis and following the biochemical changes associated with this process, the inhibition of phagocytosis by fluoride or iodoacetate was shown to be partially reversed by pyruvate. This reversal occurred with both inhibitors, either aerobically or anaerobically. Nicotinamide adenine dinucleotide (NAD) apparently increased the degree of pyruvate reversal when fluoride, but not iodoacetate, was the inhibitory agent. Lactate under some conditions was also shown to reverse the inhibition. It is suggested that pyruvate and NAD are key compounds for the phagocytic process.

¹ Charlton Fellow, Department of Obstetrics and Gynecology, Tufts University School of Medicine.