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BIOSYNTHESIS OF RIBOSE AND DEOXYRIBOSE IN PSEUDOMONAS SACCHAROPHILA¹

^a Department of Biological Chemistry and The Institute of Industrial Health, The University of Michigan, Ann Arbor, Michigan
^b Department of Dermatology and The Institute of Industrial Health, The University of Michigan, Ann Arbor, Michigan

ABSTRACT

FOSSITT, DEXTER D. (University of Michigan, Ann Arbor), AND I. A. BERNSTEIN. Biosynthesis of ribose and deoxyribose in Pseudomonas saccharophila. J. Bacteriol. 86:1326–1331. 1963.—The biosynthesis of ribose and deoxyribose in Pseudomonas saccharophila was studied by radioisotope-tracer techniques. Patterns of C¹⁴ in ribose isolated from the nucleic acids of cells grown on labeled glucose suggested that pentose was made by the pathway involving transaldolase and transketolase. When cells were grown on radioactive gluconate, the tracer patterns indicated the possibility of a new pathway for the biosynthesis of ribose. Isotopic patterns in deoxyribose, in general, were consistent with the pathway involving reduction of ribonucleotides to deoxyribonucleotides. Certain aspects of the data, however, were not explained by this known pathway.

² Present address: Department of Biochemistry, Michigan State University, East Lansing.

¹ This paper is taken from a dissertation submitted by Dexter D. Fossitt to the Graduate School of The University of Michigan in partial fulfillment of the requirements for the Ph.D. degree. A preliminary account of this work was presented at the 60th Annual Meeting of the Society of American Bacteriologists, Philadelphia, Pa., May, 1960.