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DRUG RESISTANCE OF ENTERIC BACTERIA II.

Transduction of Transmissible Drug-Resistance (R) Factors with Phage Epsilon¹

^a Department of Microbiology, School of Medicine, Gunma University, Maebashi, Japan

ABSTRACT

HARADA, KENJI (Gunma University, Maebashi, Japan), MITSUO KAMEDA, MITSUE SUZUKI, AND SUSUMU MITSUHASHI. Drug resistance of enteric bacteria. II. Transduction of transmissible drug-resistance (R) factors with phage epsilon. J. Bacteriol. 86:1332–1338. 1963.—Transmissible drug-resistance (R) factors, which transfer resistance to tetracycline (TC), chloramphenicol, streptomycin, and sulfonamide by cell-to-cell contact, were found to be transduced in the system of Salmonella E group with phage epsilon (₁₅ and ₃₄). The R⁺ transductants of S. newington (S-84) and S. chittagong (S-224) were all found to be unable to transfer their R factors by conjugation, and their R factors were not eliminated by treatment with acridine dyes so far as tested. The R factors containing TC resistance were consistently segregated when transduced. At low multiplicities of infection, the R⁺ transductants with ₁₅ were all nonlysogenic and unable to produce normal ₁₅ phage particles; among the R⁺ transductants with ₃₄, 34% were lysogenic and 66% were sensitive to ₃₄.

¹ The outline of this paper was published in Med. Biol. (Tokyo) 62:13–16, 1962 (in Japanese).

This article has been cited by other articles:

• Davies, J. E., Rownd, R. (1972). Transmissible Multiple Drug Resistance in Enterobacteriaceae. Science 176: 758-768