This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Summers, D. F. Articles by Hasenclever, H. F. Search for Related Content PubMed PubMed Citation Articles by Summers, D. F. Articles by Hasenclever, H. F.

IN VITRO INHIBITION OF YEAST GROWTH BY MOUSE ASCITES FLUID AND SERUM

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, U.S. Public Health Service, Bethesda, Maryland

ABSTRACT

SUMMERS, DONALD F. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.), AND H. F. HASENCLEVER. In vitro inhibition of yeast growth by mouse ascites fluid and serum. J. Bacteriol. 87:1–7. 1964.—A nondialyzable heat-stable factor(s) present in experimentally produced mouse ascites fluid and in serum from these ascitic mice was shown to inhibit the invitro growth of several yeasts. The inhibitory activity was almost totally abolished by trypsin treatment of the ascites fluid, and was progressively diminished by repeated adsorption of the ascites fluid by heat-killed Candida albicans cells. A close relationship was shown to exist between growth inhibition by ascites fluid and concentration of free iron or nutrients in the growth medium. Increased concentration of nutrients or free iron caused diminution of inhibitory activity.