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FLUORESCENT-ANTIBODY STUDIES OF THE MYCELIAL FORM OF HISTOPLASMA CAPSULATUM AND MORPHOLOGICALLY SIMILAR FUNGI

Communicable Disease Center, U.S. Public Health Service, Department of Health, Education, and Welfare, Atlanta, Georgia

ABSTRACT

KAUFMAN, LEO (Communicable Disease Center, Atlanta, Ga.), AND BRENDA BRANDT. Fluorescent-antibody studies of the mycelial form of Histoplasma capsulatum and morphologically similar fungi. J. Bacteriol. 87:120–126. 1964.—Fluorescent-antibody reagents were developed to differentiate the mycelial form of the pathogen, Histoplasma capsulatum, from several morphologically similar but saprophytic species of the genera Sepedonium and Chrysosporium. Cross-staining and adsorption procedures revealed antigenic relationships among certain species of these three genera and other fungi. The significance of these observations to the diagnostician and taxonomist is discussed.