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J Bacteriol. 1965 July; 90(1): 116-119
Copyright © 1965 American Society for Microbiology. All Rights Reserved.

Isolation of Antigens of Pasteurella pestis I. Lipopolysaccharide-Protein Complex and R and S Antigens

^a U.S. Army Medical Unit, Fort Detrick, Frederick, Maryland

ABSTRACT

LARRABEE, ALLAN R. (Fort Detrick, Frederick, Md.), JOHN D. MARSHALL, AND DAN CROZIER. Isolation of antigens of Pasteurella pestis. I. Lipopolysaccharide-protein complex and R and S antigens. J. Bacteriol. 90:116–119. 1965.—Pasteurella pestis contains at least 18 different antigens, 2 of which will protect experimental animals from challenge infection. A specific polysaccharide isolated and described as a hapten was isolated as a complete antigen. Two additional antigens were isolated from P. pestis. The preparation of antisera directed against these three antigens and the content of protein, lipid, and carbohydrate of each preparation were studied. None of the preparations will protect mice from challenge infection with virulent P. pestis. A basis for naming the new antigens which does not conflict with previously published designations is presented.

¹ Present address: National Heart Institute, Laboratory of Biochemistry, National Institutes of Health, Bethesda, Md.