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J Bacteriol. 1965 September; 90(3): 623-628
Copyright © 1965 American Society for Microbiology. All Rights Reserved.

Mode of Action of the Antiviral Activity of Amantadine in Tissue Culture¹

^a Pharmaceutical Research Division, Industrial and Biochemicals Department, and Central Research Department, E. I. du Pont de Nemours & Co., Inc., Wilmington, Delaware

ABSTRACT

HOFFMANN, C. E. (E. I. du Pont de Nemours & Co., Inc., Wilmington, Del.), E. M. NEUMAYER, R. F. HAFF, AND R. A. GOLDSBY. Mode of action of the antiviral activity of amantadine in tissue culture. J. Bacteriol. 90:623–628. 1965.—Amantadine hydrochloride has shown antiviral activity in tissue culture, in ovo, and in vivo. Experiments with it during the course of virus proliferation indicate that its antiviral activity is due to inhibition of virus penetration into the host cell. These studies indicate that amantadine hydrochloride is not virucidal at concentrations active in tissue culture. It does not block virus adsorption to host cells, nor does it affect the virus enzyme neuraminidase. In the presence of amantadine hydrochloride, virus adsorbed to susceptible cells remains at the cell surface in an infective state. An attempt to demonstrate high development of resistance to the antiviral action of amantadine hydrochloride in tissue culture has been unsuccessful.

² Present address: Smith Kline & French Laboratories, Philadelphia, Pa.

¹ Contribution no. 1089 from the Central Research Department.

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