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J Bacteriol. 1965 September; 90(3): 744-747
Copyright © 1965 American Society for Microbiology. All Rights Reserved.

Cyanide Resistance in Achromobacter II. Mechanism of Cyanide Resistance

^a Laboratory of Fermentation, Department of Agricultural Chemistry, University of Tokyo, Tokyo, Japan

ABSTRACT

OKA, TETUO (University of Tokyo, Tokyo, Japan), AND KEI ARIMA. Cyanide resistance in Achromobacter. II. Mechanism of cyanide resistance. J. Bacteriol. 90:744–747. 1965.—Photochemical data showed that the only oxidase found in the cyanide-sensitive cells of Achromobacter was cytochrome o, and that cyanide-resistant cells contained at least two oxidases. The oxidase responsible for cyanide resistance was a pigment the CO compound of which had its absorption band at a wavelength longer than 580 mµ. In addition, kinetic data suggested that there were two oxidases having different affinities for cyanide. From the data presented, resistance to cyanide in Achromobacter strain D was attributed to the induced formation of cytochrome a₂, which has a very low affinity for cyanide. Several characteristics of cytochrome a₂ as a cytochrome oxidase are summarized.

¹ Present address: Kyowa Hakko., Co Tokyo Research Laboratory, Machida, Tokyo, Japan.