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J Bacteriol. 1965 October; 90(4): 984-988
Copyright © 1965 American Society for Microbiology. All Rights Reserved.

Formation of Lactyl-Coenzyme A and Pyruvyl-Coenzyme A from Lactic Acid by Escherichia coli

Department of Biochemistry, Albert Einstein Medical Center, Philadelphia, Pennsylvania

ABSTRACT

MEGRAW, ROBERT E. (Albert Einstein Medical Center, Philadelphia, Pa.), HENRY C. REEVES, AND SAMUEL J. AJL. Formation of lactyl-coenzyme A and pyruvyl-coenzyme A from lactic acid by Escherichia coli. J. Bacteriol. 90:984–988. 1965.—Cell extracts of propionate-adapted Escherichia coli were found to contain a lactyl-coenzyme A (CoA) synthetase which catalyzes the formation of the CoA thiolester from lactate, CoA, and cofactors. The extracts also catalyzed the nicotinamide adenine dinucleotide-dependent oxidation of lactyl-CoA. The product of this oxidation was identified chromatographically as pyruvyl-CoA.

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