This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Takano, K. Articles by Neal, A. L. Search for Related Content PubMed PubMed Citation Articles by Takano, K. Articles by Neal, A. L.

 Previous Article  |  Next Article 

J Bacteriol. 1965 December; 90(6): 1542-1547
Copyright © 1965 American Society for Microbiology. All Rights Reserved.

Nucleic Acid-Induced Resistance to Viral Infection

Department of Biologics Research, Chas. Pfizer & Co., Inc., Terre Haute, Indiana

ABSTRACT

TAKANO, KOUICHI (Chas. Pfizer & Co., Inc., Terre Haute, Ind.), JOEL WARREN, KEITH E. JENSEN, AND ALAN L. NEAL. Nucleic acid resistance to viral infection. J. Bacteriol. 90:1542–1547. 1965.—Administration of nonviral nucleic acids to mice increased their resistance to a subsequent infection with influenza or encephalomyocarditis viruses. Injection of ribonucleic acid or deoxyribonucleic acid by peripheral routes did not modify susceptibility to intranasal infection. Lung tissue extracts from animals previously treated with yeast nucleic acid inhibited the growth of vaccinia and influenza viruses. The protective effect of exogenous nucleic acids persisted in mice for several days, but gradually diminished to undetectable levels.