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J Bacteriol. 1966 December; 92(6): 1689-1697
Copyright © 1966 American Society for Microbiology. All Rights Reserved.

Metabolism of D-Mannose in Aerobacter aerogenes: Evidence for a Cyclic Pathway1

M. Y. Kamel2 and R. L. Anderson

a Department of Biochemistry, Michigan State University, East Lansing, Michigan

ABSTRACT

KAMEL, M. Y. (Michigan State University, East Lansing), AND R. L. ANDERSON. Metabolism of D-mannose in Aerobacter aerogenes: evidence for a cyclic pathway. J. Bacteriol. 92:1689–1697. 1966.—Evidence is presented which suggests a cyclic pathway for the constitutive utilization of D-mannose in extracts of Aerobacter aerogenes PRL-R3. D-Mannose is phosphorylated with D-glucose-6-phosphate to yield D-mannose-6-phosphate and D-glucose. D-Glucose-6-phosphate may be regenerated by isomerization of D-mannose-6-phosphate through D-fructose-6-phosphate, or by phosphorylation of D-glucose with adenosine-5'-triphosphate. The pathway involves the participation of four constitutive enzymes: D-glucose-6-phosphate isomerase, D-mannose-6-phosphate isomerase, a stereospecific D-glucokinase, and a phosphotransferase which phosphorylates D-mannose with D-glucose-6-phosphate, acetyl phosphate, or carbamyl phosphate. The absence of D-mannokinase (adenosine-5'-triphosphate:D-mannose phosphotransferase) activity in extracts of this organism suggests that the pathway may be of functional significance. Also, the pathway accounts for an apparent 2-epimerization of D-mannose to D-glucose that was observed in extracts.

FOOTNOTES

2 Predoctoral Fellow of the Egyptian Government.

1 Journal Article No. 3697 from the Michigan Agricultural Experiment Station.

J Bacteriol. 1966 December; 92(6): 1689-1697
Copyright © 1966 American Society for Microbiology. All Rights Reserved.





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