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J Bacteriol. 1966 December; 92(6): 1812-1820
Copyright © 1966 American Society for Microbiology. All Rights Reserved.

Ultraviolet Microscopy of Candida albicans

Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois

ABSTRACT

BALISH, EDWARD (Argonne National Laboratory, Argonne, Ill.), AND GEORGE SVIHLA. Ultraviolet microscopy of Candida albicans. J. Bacteriol. 92:1812–1820. 1966.—Yeast and mycelial strains of Candida albicans were grown in medium supplemented with sulfur amino acids in an effort to determine factors that control the morphology and pathogenicity of the organism. Ultraviolet microscopy revealed a greater concentration of S-adenosylmethionine in the vacuoles of the mycelial phase than in those of yeast phases. Supplementation with amino acids greatly increased the concentration of S-adenosylmethionine in the mycelial phase, and made these cells more sensitive to the lytic action of snail gut enzymes than two yeast phase strains. This indicates a difference in cell wall structure that may be related to the pathogenicity of the mycelial phase.