This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Harrison, E. F. Articles by Zygmunt, W. A. Search for Related Content PubMed PubMed Citation Articles by Harrison, E. F. Articles by Zygmunt, W. A.

Lysostaphin in Experimental Renal Infections

Department of Microbiology and Natural Products Research, Mead Johnson Research Center, Evansville, Indiana

ABSTRACT

By use of a renal staphylococcal infection model in mice, single intravenous doses of lysostaphin ranging from 1.56 to 50 mg/kg were effective in: (i) controlling the staphylococcal population of kidneys, (ii) reducing the mortality rate, and (iii) clearing high numbers of kidneys of infection. Semisynthetic penicillins and other antistaphylococcal antibiotics given in the same manner did not have significant activity. Only by the administration of a long-acting, depot form of penicillin (Bicillin) could results comparable to those seen with lysostaphin be obtained. The results of this study suggest that lysostaphin may be useful in staphylococcal septicemias in preventing the establishment of new foci of infection.

This article has been cited by other articles:

• Yang, X.-Y., Li, C.-R., Lou, R.-H., Wang, Y.-M., Zhang, W.-X., Chen, H.-Z., Huang, Q.-S., Han, Y.-X., Jiang, J.-D., You, X.-F. (2007). In vitro activity of recombinant lysostaphin against Staphylococcus aureus isolates from hospitals in Beijing, China. J Med Microbiol 56: 71-76 [Abstract] [Full Text]  
• Kiri, N., Archer, G., Climo, M. W. (2002). Combinations of Lysostaphin with {beta}-Lactams Are Synergistic against Oxacillin-Resistant Staphylococcus epidermidis. Antimicrob. Agents Chemother. 46: 2017-2020 [Abstract] [Full Text]  
• Climo, M. W., Ehlert, K., Archer, G. L. (2001). Mechanism and Suppression of Lysostaphin Resistance in Oxacillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 45: 1431-1437 [Abstract] [Full Text]  
• Patron, R. L., Climo, M. W., Goldstein, B. P., Archer, G. L. (1999). Lysostaphin Treatment of Experimental Aortic Valve Endocarditis Caused by a Staphylococcus aureus Isolate with Reduced Susceptibility to Vancomycin. Antimicrob. Agents Chemother. 43: 1754-1755 [Abstract] [Full Text]  
• Climo, M. W., Patron, R. L., Goldstein, B. P., Archer, G. L. (1998). Lysostaphin Treatment of Experimental Methicillin-Resistant Staphylococcus aureus Aortic Valve Endocarditis. Antimicrob. Agents Chemother. 42: 1355-1360 [Abstract] [Full Text]