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Platinum-Induced Filamentous Growth in Escherichia coli¹

^a Biophysics Department, Michigan State University, East Lansing, Michigan

ABSTRACT

Certain group VIIIB transition metal compounds were found to inhibit cell division in Escherichia coli, causing marked filamentous growth. Gram-negative bacilli were the most sensitive to this effect, whereas gram-positive bacilli responded only at near-toxic levels of the metal. None of the cocci tested showed any apparent effect. Cytokinesis (cross-septation) can be initiated by removal or decrease of platinum, but not by treatment with pantoyl lactone, divalent cations, or a temperature of 42 C.

² Present address: Michigan Department of Public Health Laboratories, Lansing, Mich.

³ Present address: Faculty of Science, Division of Biophysics, Charles University, Prague, Czechoslovakia.

¹ Presented in part at the 66th Annual Meeting of the American Society for Microbiology, Los Angeles, Calif., May 1966.

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