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Kinetics of Lethal Adsorption of Colicin E2 by Escherichia coli

Public Health Laboratory, Canynge Hall, and Department of Bacteriology, The Medical School, University of Bristol, Bristol, England

ABSTRACT

The kinetics of lethal adsorption of colicin E2 by Escherichia coli C6 were studied by means of survivor plots. These were determined by a method which allowed rapid sampling of the reaction mixture and estimation of approximate confidence limits for the plotted data. The results were consistent with the predictions of a hypothetical model that assumed a single-hit mechanism of colicin action upon a bacterial population whose cells varied in their number of specific (lethal) receptors for colicin. The possibility of nonlethal adsorption is discussed.