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Local and Regional Applications of Hydrogen Peroxide in the Control of Clostridial Myositis in Rabbits

Department of Microbiology, Graduate Division at the College of Dentistry and Charles A. Sammons Research Division, Baylor UniversityMedical Center, Dallas, Texas

ABSTRACT

The intra-arterial infusion of hydrogen peroxide has been used as a method for producing a hyperoxic environment in experimental animals for the treatment of experimentally induced clostridial myositis. Eighty-five rabbits were employed in this study; 43 were controls and 42 were experimental animals. In the experimental study, 21 animals were treated with hydrogen peroxide by each route of administration. In this group, 52.4% of the animals receiving the intra-arterial infusion and 66.6% receiving intramuscular clysis survived. There were no survivors past 72 hr in the control group.