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Physiology of Rickettsiae VII. Amino Acid Incorporation by Coxiella burnetii and by Infected Hosts

^a Department of Microbiology, University of Kansas, Lawrence, Kansas 66044

ABSTRACT

Protein synthesis, in terms of ¹⁴C-labeled amino acid incorporation into a hot trichloroacetic acid fraction, was studied in cell-free preparations of Coxiella burnetii, and in uninfected and Q fever-infected guinea pig and chick embryo hosts. Purified and disrupted suspensions of C. burnetii incorporated ¹⁴C-labeled L-leucine, L-phenylalanine and algal hydrolysate. Livers of infected guinea pigs and chick embryos had a greater incorporation rate at the height of infection than comparable preparations from uninfected animals. As chick embryonic development continued during infection, the rate of incorporation progressively decreased below that of uninfected embryos.

¹ Present address: Department of Bacteriology and Public Health, Washington State University, Pullman 99164.