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Bacteriocin Produced by Bordetella pertussis¹

^a Department of Microbiology, University of Louisville School of Medicine, Louisville, Kentucky 40202

ABSTRACT

Of the 24 strains of Bordetella pertussis examined, 2 produced bacteriocins that inhibited the growth of all but 2 other strains of this species. The two strains producing the bacteriocin and the two resistant strains were rough, whereas all susceptible strains were smooth. The bacteriocin was not active on the B. parapertussis or B. bronchiseptica strains tested. These bacteriocins appeared to be protein in nature, since they were heat-labile and partially inactivated by trypsin. They were antigenic but the neutralizing antibodies did not precipitate the antigens. Absorption of the antiserum with homologous cell suspensions removed the agglutinating, but not the neutralizing, antibody.

¹ Based on portions of a dissertation submitted by Claudia Litkenhous to the University of Louisville, in partial fulfilment of the requirements for the M.S. degree.