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Thymineless Death in Escherichia coli: Strain Specificity

Department of Microbiology, University of Colorado Medical Center, Denver, Colorado 80220

ABSTRACT

Thymineless death of various ultraviolet (UV)-sensitive strains of Escherichia coli B and K-12 was investigated. It was found that E. coli B, B_s–12, K-12 rec-21, and possibly K-12 Lon^–, all sensitive to UV, were also sensitive to thymine starvation. However, other UV-sensitive strains of E. coli were found to display the typical resistant-type kinetics of thymineless death. The correlation of these results with various other cellular processes suggested that the filament-forming ability of the bacteria might be involved in the mechanism of thymineless death. It was apparent from the present results that capacity for host-cell reactivation, recombination ability, thymine dimer excision, and probably induction of a defective prophage had little to do with determining sensitivity to thymine deprivation.

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• Zaritsky, A., Woldringh, C. L., Einav, M., Alexeeva, S. (2006). Use of thymine limitation and thymine starvation to study bacterial physiology and cytology.. J. Bacteriol. 188: 1667-1679 [Full Text]